Two American Pioneers: Seba Smith and Elizabeth Oakes Smith

ELIZABETH S . FENJVES , JONATHAN SMITH , ' SANDY ZARADIC , and LORNE B

Grafts of autologous keratinocytes genetically altered to secrete a new gene product are a potential vehicle for gene therapy. T o consider the feasibility of such an approach, w e have examined the ability of keratinocytes to secrete and deliver apolipoprotein E (apoE) to the circulation of mice bearing grafts of h u m a n keratinocytes. The grafted keratinocytes secreted two forms of apoE, an...

The Same Face of the Two Smiths: Adam Smith and Vernon Smith

Religion and Spirituality: Adam Smith versus J-J Rousseau

Adam Smith and J-J Rousseau share some common ground when it comes to religion, namely that they were born into  and educated in cultural contexts deeply shaped by Reformed Christianity. However, close consideration of their writings on religion reveal marked difference. This paper explores those differences and finds that Rousseau and Smith are radically at odds on this score. Smith has almost...

Two cases of Smith-Magenis syndrome

SmithMagenis syndrome (SMS) is a rare disorder with multiple congenital anomalies caused by a heterozygous interstitial deletion involving chromosome 17p11.2, where the retinoic acid-induced 1 (RAI1) gene is located, or by a mutation of RAI1. Approximately 90% of the patients with SMS have a detectable 17p11.2 microdeletion on fluorescence in-situ hybridization (FISH). SMS is characterized by m...

The Same Face of the Two Smith

Going from personal to impersonal exchange seems to be a relevant feature that allows humans to develop complex societies and grow prosperous. Adam Smith’s idea of moral imagination, embodied in the impartial spectator and achieved through sympathy, may integrate and complement today’s evolutionary biology and experimental economic explanations, providing the missing key as to how we generate a...